In the dizzying world of New York fashion, where a bad haircut can kill your entire career, Runway magazine is the dream Olympus for anyone who cares even a little about their appearance. Run by the fashion industry's most powerful woman, Miranda Priestly (Meryl St reep), who rules it with a heavy hand and perfectly manicured nails, Runway is the dreaded test that everyone who wants to make a difference in this world must pass. In fulfilling her mission to make Runway the fashion bible of New York, and therefore the world, she will not let anything stand in her way... including a long line of assistants who have fallen short of her expectations. It's a job no one with a shred of self-respect can stand - but it's also a job millions of young New Yorkers would kill for. Miranda's assistant job could be the gateway to the big world of fashion for fresh out of a prestigious college, Andy Sachs (Anne Hathaway). In a bland outfit that fits her more like a shy student than a modern woman, she looks like a fist in the eye among the army of uptight fashion dragons crisscrossing the halls of Manhattan magazine headquarters in stiletto-heeled shoes.
Within her first visit, it becomes clear that success in this industry requires more than just passion and determination. Although Miranda has the fashion world wrapped around her finger, she has great difficulty finding and keeping a good assistant. Andy is absolutely not the right person for the job. But she has something that the other candidates lack: She's not going to accept failure. To become the perfect assistant, she must change to Miranda's liking. Soon she can - to her boyfriend's (Adrian Grenier) not-so-much enthusiasm - talk like a first-class connoisseur of modern trends, walk like a model and no longer confuses Dolce with Gabbana under any circumstances. But the more she sees through Miranda's eyes, the more she realizes that her new world is a wonderful but very unforgiving place - and that succeeding in it sometimes requires great sacrifice.