In a world infested with a viral infection that turns its victims into the undead, Alice (Milla Jovovich) continues on her quest to find survivors and lead them to safety. Her deadly battle with the Umbrella Corporation reaches new heights, but Alice gets unexpected help from an old friend.
A new lead that promises a safe heaven from the Undead leads them to Los Angeles, but when they arrive, the city is infested with thousands of Undead - and Alice and her companions are caught in a deadly trap...
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